Monday, 10 June 2013

Antbibiotics - They don't work, stop asking for them

Ok so the title is a bit of a lie, they do work but they shouldn't be used as indisciminantly as they are. Why has it been so long I hear all my great followers (Robyn) cry? Well I've been busy and I've been ill.

Now this wasn't some little case of man flu with sniffles, this was great swathes of yellow mucous, coughing, fever and muscle pains. So what did I do? Run off to get antibiotics? Screw that I knocked back good old fashioned over the counter painkillers and waited it out.

Now why would I pass up a chance to take these miraculous anti biotics? Well it was a combination of I hate taking the things and that my illness was primarily viral so antibiotics will have no effect. There might have been a certain placebo effect but all I would be doing it wiping out those nice commensal bacteria in my gut making secndary infection more likely and giving me a rather upset stomach.

But people are surely crying how they don't have bacteria in their gut unless they're ill....Bullshit, your body is a melting pot of bacterial life both inside and out. Most of it you would never notice, the gut flora especially unless something changes that delivcate balance and that something can be those lvoely anti biotics you think are making you better. Sure you can swig all the pro biotic drinks you want but it still doesn't stop the fact you're exposing your body to chemicals it doesn't need to be exposed to.

And why is that so bad? Well vancomycin for example can damage your kidneys quite nicely. There's also the fact you're actively pushing the evolution of bacteria who, let's face it are sneaky little genetic sponges. If a bacterium can find a gene that gives it partial resistance to an antibiotic lying around in its environment it will soak it up and try to use it, likewise if it completes a gene that frisky bacterium can pass the gene onto its cohorts or just divide rapidly in the space its less resistant cohorts once occupied. And that is the simple story of how MRSA and VRE came about. There's a much longer version involving selective environments, pili, raunchy bacterial sex and the like but what it comes down to is over use of antibiotics is selecting for an antibiotic resistant world.

Sadly some people still see them as the cure all when they're feeling lousy as they "know" antibiotics make them better which brings the placebo effect to light. Would people respond just as well to an over the counter drug with a long name that was essentially a sugar, caffeine and salt pill if there was a big enough marketing campaign telling them it worked? Possibly, the placebo effect is very strange.

So how can I sum this up? If you're tired, ill and achey then normal non steroidal anti inflammatories such as ibuprofen and a cup of hot, sweet tea will often do the job. Just rest up safe in the knowledge that you feel so crap because your immune system is going all out dealing with whatever the cause of the infection is.

Wednesday, 8 May 2013

Science in entertainment

Ok, I'll be serious here. I know two posts in two days must be some sort of apocalyptic sign but I'll risk it so here goes. I shall mostly be talking about how entertainment is constantly bending science over the bar counter and having its way with poor lost science who only wanted a drink of water so to speak.

1: Shrink Rays
Yes they all seem like fun but what do they do? They decrease something's physical size but there is no mention of one rather important factor. Mass. The mass or weight would remain constant, the object would just become incredibly dense. Think of it this way, if you put a car in a crusher that 2 ton metal construct will weight two tons regardless of if it's the original car shape of the much smaller cube.

So let's say you shrank the Moon and bought it to Earth. It might be small but that small lump of rock would have a mass of around 7.35x10^22 Kg. Couple in Earth's gravity as weight is mass x gravity and you're left with a very heavy mall of rock that would be exerting it's own gravity on you anyway and causing all kinds of interesting problems.

Ok so how about shrinking people? Well same problem applies, if you weighed 50Kg before shrinking, you'll weigh that after but you'll exert more pressure as your weight will be concentrated over a smaller area. What does this mean? If you go walking along the beach be prepared just to sink in the sand and wait for the inevitable. There's always the problem of nutrition too, remember everything about you is so much smaller than it once was and this includes all those lovely enzymes you need for life. Now let's say you were thirty so you had a drink, seems fair doesn't it? But what if all those non shrunken water molecules are now simply too big to do their osmotic thing and dehydrate you? What is the food you eat is simply too big for your enzymes to work on? Well they your days are numbered.

Take home message: If you think something should be smaller, use less materials when manufacturing it or simply crush it. Don't shrink large objects or living things.

2: Enlargement rays
Is the world getting you down? Do you just feel the need to go on a Godzilla style rampage to blow off some steam? Did you just buy or invent and enlargement ray to do that? Well I suggest you take a minute to look up.
 As with shrinking, making yourself bigger will not increase your mass. This means you'll still be 80Kg but a much bigger target. You wouldn't be crushing cars underfoot, you're more likely to trip over them. Can you punch through concrete walls now? Well don't suddenly expect to unless you can increase the force behind your blows your fists will weigh the same and due to their increased size will exert less pressure over that wall you hate so much.

Also think about food, roasting a cow might seem like a good idea but remember, your enzymes are now way too big for their substrates. They simply won't work. Think you can always shrink yourself to eat? Well remember oxygen? Do you think your oversized  haemoglobin will bind that teeny tiny little molecule properly now? Think the electron transfer chain will happily accept it? Well let me know how it turns out because the risk of hypoxia doesn't seem worth it.

3: Explosions in space
Everyone loves them in films, they look cool, sound better with all that bass and make it all worthwhile. What a shame you would never hear them, all those cool laser firing effects. Why is that? Well what is sound? It's vibrations which hit our eardrum which are they amplified and passed onto the cochlea where fluid moving hairs on cell surfaces creates nervous impulses.

What's the point of this? Well space generally lacks anything dense enough to transmit vibrations through. If it did it would suggest that for us to hear everything with such clarity space was filled with a gas with the same density as our atmosphere. So why do we perpetuate this lie? Well would the Death Star explosion have been as impressive if it was just a silent light show? If you say no then it's your fault this lie lives with us to this day.

4: The scientific MacGuffin.
This can take many forms but it is always a plot device explained by science which is invaluable later on. Let's take one example shall we? The use of EDTA to explode vampires. 
EDTA or ethylenediaminetetraacetic acid is commonly used as an anticoagulant. Often as the sodium or potassium salt which is a lovely white power and dissolves into a colourless solution (not a blue one). Ok but what does EDTA do? It sequesters divalent ions that is ions which carry a 2+ charge like calcium. Now calcium is good at making our teeth and bones strong, it's also required to form clots when you start bleeding. When EDTA comes along it grabs all those calcium ions and keeps them to itself stopping clots forming.

Now this particular franchise likened vampirism to a virus, so let's ask why removing a small amount of calcium would make a vampire explode? Does this virus become highly volatile with very minute changes in circulating calcium or does it trigger instant proliferation of blood cells causing things to explode if just one of those precious calcium ions is removed? I would say this is highly unlikely. So why use it? Well people have heard of EDTA although they probably don't know what it actually does so this knowledge was abused to drive the plot forward. This is the important thing, this entertainment relies on ignorance to be effective.

So there you are, 4 little examples of how movies are used to make money off of us while perpetuating fallacy and relying on the ignorance of the public. When it comes down to it the writers are basically saying "because it's scientific we don't have to explain it because you won't understand anyway" so take you time to think. Was that movie really cool or was it insulting your intelligence while taking your money?

Tuesday, 7 May 2013

Post the third

Well I never promised regular posts now did I?

So what's next on my list after telling you it's OK to break reality I shall pretend you asked.....well I could talk about scientific quackery and how "science" can be manipulated to dupe people. However if you want that find a lovely book written by Ben Goldacre. Instead I shall talk about blood groups.

There are more than you think, blood goes beyond A B O positive and negative. There are many others which have lovely names like Duffy, Kelly, Lewis and Kidd and can mostly be ignored unless people develop allowed antibodies against them. So why bring them up? Well mostly just to say blood transfusion can be more complicated than shoving Opos from one person into another Opos person, it's not without some risk.

These antibodies make people harder to transfuse and can have other impacts especially if you're a pretty menopausal woman. But scare mongery aside the real question is how many know their blood group? How many donate? Probably not enough. So even if it is to be nosy and find out if you're an A B or O go give blood. You never know when you might need it yourself.

Well that's been way too serious so now consider this...if we used copper instead of iron in red cells as our oxygen carrier of choice, our blood would be as blue as the noble mantis shrimp.

Thursday, 18 April 2013

How can I top raunchy photos of white blood cells?

Well I can be a little sarcastic and raise a counter argument to a truly great article found here:

Paradoxes can be solved by science and janitorial aids.

That's right folks, if you do manage to create a paradoxical double of yourself you're safe in the knowledge that the duplicate is always doomed. This could be especially handy if you need to pull the ultimate escape and get away from it all. It might be a pain trying to prove you're really alive and that other body was just a spare later on but why worry about that now, you have a time machine.

Narcissism - how much do you love yourself. Why not pop back to last night and find out? It also takes care of all those annoying little setbacks when considering a threesome. If you don't want to include someone else why not have two of you? I mean if you end up enjoying yourself in the process it's basically masturbation right?

In a well thought out, well planned universe there should be back up plans for time travel. Reality hasn't noticeably ripped itself apart so if space-time travel has been invented we can assume it's all fine and good. But if you do decide to go for a quick jaunt to the past, don't do anything unless you were meant to do it. Then whatever you do, don't not do it.

Spare parts - let's face it the human body is pretty fragile. Why wait on transplant lists when you can just nip back, grab a double of yourself and get a perfect match? Remember point 1, that double is doomed anyway so don't worry about it and just enjoy that kidney for a few more years.

Ok so not a set of well thought out and planned examples but still is reality all that great when it all comes down to it. If you do end up playing a hand in its downfall at least you'll be known as the harbinger of the apocalypse or the guide to some kind of golden Eutopia of reality 2.0. Either way it's more recognition than you'll probably get now.

Wednesday, 17 April 2013

numero uno

So yeah, typically don't blog but created this on a whim for the hell of it. Not much else to put really for now. If you're unlucky enough to stumble upon this you have my colndolences. Until then, here's a nice photo of leukaemia:
You now have permission to back away slowly.